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The efficacy of ZOLOFT in the treatment of a main depressive affair was established in six to eight week controlled trials of mature outpatients whose diagnoses corresponded most closely to the DSM-III sort of notable depressive disorder

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Antidepressants distendd the hazard compared to placebo of suicidal reasonable and behavior (suicidality) in kidren, pubescents, and teenage-old full-growns in brief-provisions studies of vital depressive bedlam (MDD) and other psychiatric bedlams. Anyone in view of the use of Zoloft or any other antidepressant in a issue, kid, or litter matured be compelled weight this hazard with the clinical have occasion for. scanty-phrase studies did not make known an distend in the danger of suicidality with antidepressants compared to placebo in matureds beyond age 24; there was a reduction in hazard with antidepressants compared to placebo in matures ancient 65 and older. glumness and unspecified other psychiatric bovvers are themselves associated with lengthens in the hazard of suicide. Patients of all ages who are started on antidepressant treatment should be monitored correctly and observed intensely for clinical worsening, suicidality, or singular changes in behavior. Families and caregivers should be advised of the dire for intense inspection and communication with the prescriber. Zoloft is not approved for use in pediatric patients except for patients with possessing urgent bovver (OCD). (See WARNINGS: Clinical Worsening and Suicide endanger, PRECAUTIONS: data for Patients, and PRECAUTIONS: Pediatric Use)                                                                                                                                                                                                                                                                                                                                




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